A Pox on Cholesterol Lowering Drugs: Statins Raise Herpes Zoster (Shingles) Risk

 

A recent study published in the journal Clinical Infectious Diseases titled, “Statins and the risk of herpes zoster” show that there are unknown association between statin drug use and increased risk of herpes zoster (shingles).

Researchers from St. Michael’s Hospital, Ontario, Canada, conducted a population-based retrospective cohort study of Ontario residents 66 years of age or older, with a study period of thirteen years. They matched 494,651 individuals treated with a statin to an equal number of individuals not treated with one.

Statistic says : “In the main analysis, the rate of herpes zoster was higher among users of statins relative to nonusers of these drugs (13.25 versus 11.71 per 1000 person-years, respectively; hazard ratio 1.13, 95% confidence interval 1.10 to 1.17). The attributable fraction of exposed individuals was 11.6%. In a prespecified analysis, we found a similar risk of herpes zoster among statin users in the subgroup of patients with diabetes (hazard ratio 1.18, 95% confidence interval 1.09 to 1.27). As expected, we found no association between statin use and knee arthroplasty (hazard ratio 1.04, 95% confidence interval 0.99 to 1.09). Conclusions. Among older patients, treatment with statins is associated with a small but significantly increased risk of herpes zoster.”

Maybe the 13% increase in the relative risk of developing shingles in statin users may seem small, it reveal something concerning not on the radar of most clinicians, nor their patients, namely, the potent immunosuppressive and/or immunotoxic properties of statin drugs.

We hope that you know that statin drugs have a multitude of physiological effects beyond their much-touted ‘cholesterol-lowering’ properties, these so-called ‘pleomorphic’ properties include ‘anti-inflammatory’ and ‘immune system modulating’ effects. This class of drugs has over 300 adverse health effects, many of which are life-threatening, including – ironically, cardiotoxicity or damage to the arteries and heart muscle
FDA approved a lot of chemicals as is the case with patenden xenobiotic chemicals, in order to make profit. Many of the drugs have adverse physiological effects that are marketed to the consumer/patient as ‘therapeutic’ effects, e.g. the side effect of ‘drowsiness’ is marketed as a sleep aid, or an immune destroying agent as a drug for autoimmune diseases.

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An example of a statin side effect marketed as a ‘beneficial effect’ is the way in which these chemicals are believed to down-regulate inflammation and/or destructive immune responses within damaged arteries. Atherosclerosis – the progressive narrowing of the arteries – has an autoimmune component whereby the immune system in response to persistent injury from environmental exposures like smoking, infection or eating oxidized polyunsaturated fats, snowballs out of control.
The immune system will try to heal the damage when the inner lining of the blood vessels is damaged. This process can spiral out of control, resulting in fulminating inflammation and immune cell infiltration at the site of damage, usually within the middle region of the artery known as the intima media. This mostly silent process, which can go on for decades without acute symptoms, leads to the formation of plaque that eventually causes lethal obstruction.
It seems that statins suppress the system they may down-regulate this harmful autoimmune process, resulting in reduced inflammation and the slowing of the pathological process in the arteries. This ‘side benefit,’ however, comes at a price. While the arteries may benefit to some degree from these immunsuppressive properties, the body as a whole may experience interference in immunosurveillance, which could result in increased risk of infection and cancer, and is one reason there is a concerning association with low cholesterol and increased risk of cancers at all sites.

Although, statin drugs can slightly reduce inflammation or autoimmune infiltration associated atherosclerosis, they have direct and indirect cardiotoxic effects to the heart muscle. And so, some patients may be trading in the lipid modulating and mildly anti-inflammatory properties of these drugs for statin-induced cardiomyopathy or heart failure — a quicker path to death and disability that atherosclerosis. And this is all the more tragic when one considers that dietary and lifestyle interventions are far more effective at reversing this process than the administration of a pharmaceutical.

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This study show that statin drugs, in suppressing the immune function, are increasing the risk of immune-related disorders such as herpes zoster – a far more debilitating form of the chicken pox virus (varicella) that the adult body is usually adept at keeping inactive. Ultimately, this is just one more nail in the coffin for the global statin propaganda machine.